Review Article

Year : 2023 | Volume : 14 | Issue : 1 | Page : 36-43

ACTN3 gene variations in various Ethnic populations and its association with Skeletal Malocclusion – A Literature Review

Ashwin Mathew George1, Nagachandran K.S.2 , Sumathi Felicita.A3 , Vijayashree Priyadarshini. J4 , Anitha. P5

1,2,3 Professor, Department of Orthodontics, Saveetha Dental College and Hospital, 4 Associate Professor, 5 Research Scholar, Clinical Genetics Lab, Centre for Cellular and Molecular research, Saveetha Dental College and Hospital

Address for Correspondence:

Nagachandran K.S., MDS

Professor, Department of Orthodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, TamilNadu, India

Email: orthodrnaga21@gmail.com Phone: +91-9884152660

Abstract:

Genetic etiology of Skeletal Malocclusion has been explored extensively over recent years with the advent of advances in molecular technologies. Studies have reported that the masticatory muscles regulate skeletal development and few recent works of literature report that the muscle growth regulators influence the facial proportions in sagittal and vertical dimensions in Skeletal Class II malocclusion. This review is a humble attempt to highlight the role of one such muscle gene known as ACTN3 and its association with Skeletal Class II malocclusion.

Keywords: Genetics, ACTN3 gene, polymorphism, masseter muscle, facial height, malocclusion

Source of Funding:

Nil.

Conflict of Interest:

The authors have no conflict of interests to declare

How to cite this article: Ashwin Mathew George, Nagachandran.K.S, Sumathi Felicita.A, Vijayashree Priyadarshini.J, & Anitha.P. (2023). ACTN3 gene variations in various Ethnic populations and its association with Malocclusion – A Literature Review: Review Article. International Journal of Orthodontic Rehabilitation, 14(1), 36–43. https://doi.org/10.56501/intjorthodrehabil.v14i1.718