Review Article
Year : 2025 | Volume : 9 | Issue : 2 | Page : 1-9
Beyond Biopsy: Leveraging Salivary Multi –Omics for Comprehensive and Non-Invasive Molecular Characterization of Oral Squamous Cell Carcinoma
Snehal Kailash Yerne 1
1- Department of Oral and Maxillofacial Pathology, Swargiya Dadasaheb Kalmegh Smruti Dental College & Hospital, Nagpur, Maharashtra, India
Address for Correspondence:
Dr. Snehal Kailash Yerne
Research Associate
Department of Oral and Maxillofacial Pathology
Swargiya Dadasaheb Kalmegh Smruti Dental College & Hospital
Nagpur, Maharashtra, India
Email: dr.snehalyerne@gmail.com
Abstract
Early detection of Oral Squamous Cell Carcinoma (OSCC) remains a major challenge due to delayed diagnosis and the limitations of conventional screening approaches. The stagnation in overall survival rates is largely attributed to late-stage detection and the subtle clinical presentation of early lesions. Detecting molecular aberrations early is critical for improving prognosis and reducing mortality. Saliva, a readily accessible biofluid, has emerged as a promising medium for detecting these early molecular changes. Salivary liquid biopsy, empowered by advanced multi-omics technologies, offers a comprehensive, non-invasive alternative. This platform is capable of capturing tumour-derived alterations across multiple molecular layers, including genomic, epigenomic, transcriptomic, proteomic, metabolomic, and microbiomic alterations. This narrative overview synthesizes current evidence on salivary multi-omics in OSCC, highlights clinically significant biomarker classes, outlines methodological considerations, and discusses translational implications for precision oral oncology. The integration of these diverse molecular signals promises the development of transformative diagnostic tools.
Keywords: Oral Squamous Cell Carcinoma (OSCC), Salivary Liquid Biopsy, Multi-Omics.
Financial support and sponsorship
Self-funded
Conflicts of interest
There are no conflicts of interest
How to cite this article:
Snehal Kailash Yerne. Leveraging Salivary Multi –Omics for Comprehensive and Non-Invasive Molecular Characterization of Oral Squamous Cell Carcinoma; Int J Orofac.Biol.2025; 9 (2):1-9.
