Review
Year : 2025 | Volume : 9 | Issue : 1 | Page : 20-26
Epidermal Non-Neoplastic Lesions: A Comprehensive Review
M.P. Brundha1*
Department of Pathology, Madha Medical College and Research Institute, Chennai-128.
Address for correspondence:
Department of Pathology, Madha Medical College and Research Institute, Chennai-128.
E‐mail: generalpath2015@gmail.com
Abstract
Epidermal non-neoplastic lesions represent a diverse and clinically significant group of skin conditions that primarily affect the epidermis and stratum corneum. These disorders are characterized by various alterations in keratinization, pigmentation, and inflammatory activity, often leading to functional impairment and considerable cosmetic concern. Although non-malignant, such lesions demand precise diagnosis and tailored therapeutic strategies to ensure effective management and improve patient outcomes. This comprehensive review provides an in-depth examination of several key non-neoplastic epidermal disorders, including ichthyosis vulgaris, lamellar ichthyosis, lichen amyloidosis, granular parakeratosis, mucosal melanotic macule, melasma, and vitiligo. Each condition is discussed with a focus on its clinical presentation, histopathological features, and current treatment modalities. Emphasis is placed on the diagnostic value of histopathology in differentiating these conditions and guiding therapy. Additionally, the review underscores the clinical importance of recognizing these lesions early, as some may mimic more serious dermatoses or cause long-term morbidity if left untreated. Future research aimed at uncovering the molecular and genetic basis of these conditions may offer novel insights into targeted therapies. Ultimately, this review serves as a practical reference for clinicians and pathologists involved in the diagnosis and management of non-neoplastic epidermal disorders.
Acknowledgment
Nil
Conflict of interest
Nil
Source of funding
Nil
How to cite this article: Brundha.M.P. (2025). Epidermal Non-Neoplastic Lesions: A Comprehensive Review. International Journal of Clinicopathological Correlation, 9(1). https://doi.org/10.56501/intjclinicopatholcorrel.v9i1.1291.
