Original Research
Year : 2025 | Volume : 9 | Issue : 2 | Page : 78-88
Comparative Efficacy of Lycopene-Hyaluronidase Versus Hyaluronidase-Dexamethasone in Grade III Oral Submucous Fibrosis
Original Research
Snehal Kailash Yerne 1*
1* Department of Oral and Maxillofacial Pathology Swargiya Dadasaheb Kalmegh Smruti Dental College & Hospital Nagpur, Maharashtra, India
Email: dr.snehalyerne@gmail.com
Abstract
Background: Oral submucous fibrosis (OSMF) is a chronic, progressive, and potentially malignant disorder commonly associated with areca nut chewing. It is characterized by inflammatory changes and fibrosis of the oral mucosa, leading to reduced mouth opening and burning sensation. The optimal medical management for advanced stages remains unclear. This study compared the clinical efficacy of two therapeutic protocols in Grade III OSMF patients. Methods: A prospective, randomized comparative study was conducted among 80 patients with clinically diagnosed Grade III OSMF. Participants were randomly divided into two groups (n = 40 each). Group A received weekly intralesional injections of hyaluronidase (1500 IU) with dexamethasone and lignocaine for 12 weeks. Group B received oral lycopene twice daily along with weekly intralesional hyaluronidase. Clinical parameters assessed included maximum interincisal mouth opening and burning sensation using the Visual Analogue Scale (VAS) at baseline, 3 weeks, 6 weeks, 3 months, and 6 months. Statistical analysis was performed for intergroup comparison. Results: Both groups showed clinical improvement; however, Group A demonstrated significantly better outcomes. At 6 months, mean mouth opening increased to 35.2 ± 1.8 mm in Group A compared to 29.4 ± 2.6 mm in Group B (p < 0.001). Burning sensation scores significantly reduced in both groups, with greater reduction in Group A (0.6 ± 0.4) compared to Group B (3.5 ± 0.8) (p < 0.001). Residual symptoms were more frequent in Group B. Conclusion: Intralesional hyaluronidase with dexamethasone is more effective than hyaluronidase with oral lycopene in improving mouth opening and reducing burning sensation in Grade III OSMF.
Acknowledgment
Nil
Conflict of interest
Nil
Source of funding
Nil
How to cite this article: Snehal Kailash Yerne, Comparative Efficacy of Lycopene-Hyaluronidase Versus Hyaluronidase-Dexamethasone in Grade III Oral Submucous Fibrosis. Int J Clinicopathol Correl. 2025; 9(2):78 88.10.56501/Int.J.Clin.Pathol.Correl..v9.i2.ijcc0133.
