Kiren. J et al

Year : 2026 | Volume : 11 | Issue : 1 | Page : 42-49

Quantification of PDGF and IGF-1β in Saliva of Obese Patients with Periodontitis and Diabetes Mellitus - A Comparative Study.

Kiren. J 1, M. Jeevitha 2, Bhavishya Balachandran 3, Allour Vaishnavi 1.

1 Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Tamil Nadu, India.

2 Department of Periodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Tamil Nadu, India.

3 Department of Periodontics, Priyadarshini dental college and Hospital, Tiruvallur, Tamil Nadu.  

Address for correspondence:

Dr. M. Jeevitha

Department of Periodontics Saveetha Dental College and Hospitals Saveetha Institute of Medical and Technical Sciences, Saveetha University, Tamil Nadu, India.

Email id: jeevitham.sdc@saveetha.com

Abstract 

Introduction: Chronic inflammatory illnesses like diabetes and periodontitis exacerbate each other's severity and deteriorate each other's prognosis. Research has indicated that diabetic individuals who have untreated periodontitis are more likely to have trouble maintaining their blood sugar levels and that people with diabetes are more likely to acquire periodontitis. Reducing gingival inflammation with periodontal therapy helps manage diabetes.

Aim: The aim of the study is to assess the levels of PDGF and IGF-1β in obese patients with periodontitis and diabetes mellitus.

Materials and Methods: 40 patients aged 30-60 years visiting the Department of Periodontics Saveetha dental college and hospitals, Chennai from December 2021 to march 2022 were categorised into 4 groups (10 patients in each group)- Group 1- Non obese and clinically healthy gingiva, Group 2 - Obese patients without periodontitis, Group 3 - Obese + periodontitis, Group 4 - Obese + Periodontitis + type 2 Diabetes mellitus. Salivary PDGF and IGF-1β levels were evaluated using human ELISA KIT. The data were statistically analysed by the One-way ANOVA test. The Newman-Keuls multiple comparison test was used to test the significance at the levels of p<0.05.

Results: There is significant difference in the level of salivary PDGF and IGF- 1β levels among different groups which inferred that PDGF and IGF-1β salivary levels were higher in group 4 compared to other groups. Conclusion: The findings compared with non-diabetic parallels, diabetic individuals have higher levels of IGF-1β and PDGF as well as more periodontal tissue damage. Hence, PDGF and IGF-1β is a useful salivary biomarker for diagnosing patients with periodontitis.

Keywords: biomarker; dental; disease; diabetes; health, innovative; obese; periodontitis

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

How to cite this Article:

Kiren. J et al., Quantification of PDGF and IGF-1β in Saliva of Obese Patients with Periodontitis and Diabetes Mellitus - A Comparative Study. Int J Soc Rehab 2026;11(1):42-49. doi: 10.56501/intjsocrehab.v11i1.ijsr0053