Review Article

Year : 2025 | Volume : 9 | Issue : 1 | Page : 34-42

Mechanisms of Chemoresistance in OSCC: The Role of Cancer Stem Cells

T. Keerthi Priyadarshini, 1

1 - Postgraduate, Vivekananda Dental College for Women, Thiruchengode.
 
Address for Correspondence:
Dr. Keerthi Priyadarshini
Postgraduate, Vivekananda Dental College for Women,
Thiruchengode.
Email: drkeerthi@gmail.com

Abstract

Oral Squamous Cell Carcinoma (OSCC) represents a major source of cancer morbidity worldwide, with an elevated incidence of resistance to treatment and recurrence. A major obstacle to managing OSCC effectively is chemoresistance, which is frequently linked to the existence and functioning of Cancer Stem Cells (CSCs). Because of their capacity for self-renewal, differentiation, and survival, these specialized cells are resistant to traditional treatments. This narrative review examines the molecular mechanisms, including as PI3K/AKT, Wnt, and Notch signaling, that underlie CSC-mediated chemoresistance in OSCC. Emerging strategies targeting CSCs and overcoming chemoresistance are also discussed, offering insights into future therapeutic approaches.

Keywords: Oral Squamous Cell Carcinoma, Cancer Stem Cells, Chemoresistance, PI3K/AKT, Wnt, Notch signaling, Targeted therapy.

Financial support and sponsorship

Self-funded

Conflicts of interest

There are no conflicts of interest

How to cite this article: Keerthi Mechanisms of Chemoresistance in OSCC: The Role of Cancer Stem Cells; Int J Orofac.Biol.2025; 9: 1:34-42.