Case Report

Year : 2025 | Volume : 9 | Issue : 2 | Page : 16-13

Atypical Adenomyoepithelioma of the Breast: A Diagnostic Dilemma

Case report

Ledesma Jeannine Anjelica1* , Yee Han Ning2, Ananta Gudi Mihir3, Tan Qing Ting4

1* Breast Department, KK Women’s and Children’s Hospital, Singapore, 229899. Surgery Department, San Pedro Hospital

Inc., Davao City, Philippines, 8000 Email: jeannineledz@gmail.com

2 Histopathology and Cytology Department, KK Women’s and Children’s Hospital, Singapore, 229899

Email: hanning.yee@mohh.com.sg

3 Histopathology and Cytology Department, KK Women’s and Children’s Hospital, Singapore, 229899

Email: Gudi.Mihir.A@singhealth.com.sg

4 Breast Department, KK Women’s and Children’s Hospital, 100 Bukit Timah Road, Singapore 229899

Email: tan.qing.ting@singhealth.com.sg

Corresponding Author

Breast Department, KK Women’s and Children’s Hospital, Singapore, 229899. Surgery Department, San Pedro Hospital Inc., Davao City, Philippines, 8000

Email: jeannineledz@gmail.com

Abstract

Adenomyoepithelioma (AME) of the breast is a rare lesion characterized by a biphasic proliferation of epithelial cells and myoepithelial cells. AME is a spectrum of disease ranging from purely benign, atypical lesions with low/uncertain malignant potential to frankly malignant with distant metastasis. Although atypical adenomyoepthieliomas typically follow a benign course, current publication suggest that it exhibits the potential for local recurrence even after negative initial margins and can undergo malignant transformation into a high-grade carcinoma. The imaging and core needle biopsy findings of an atypical adenomyoepithelioma can be difficult to differentiate from benign lesions or even invasive carcinoma. A definitive diagnosis requires an excisional biopsy with immunohistochemistry for thorough pathological review. Surgical excision with wide and clear margins is the recommended treatment for atypical AMEs. Close long-term follow-up is necessary to monitor any local or distant recurrence. We present a case of an atypical adenomyoepithelioma of the breast and discuss the diagnostic challenges and the multidisciplinary management associated with this unusual lesion.

Acknowledgment

Nil

Conflict of interest

Nil

Source of funding

Nil

How to cite this article: Ledesma Jeannine Anjelica, Yee Han Ning, Ananta  Gudi Mihir, Tan Qing Ting, Atypical Adenomyoepithelioma of the Breast: A Diagnostic Dilemma, Int J Clinicopathol Correl. 2025; 9(2):43-50. 10.56501/intjclinicopatholcorrel.v9i2.1322.